Peptide Manufacturing Overview¶

Technical knowledge base for peptide manufacturing methods, processes, and quality systems.

Sections¶

• Peptide Synthesis Overview — Complete overview of peptide manufacturing from SPPS to final product
• SPPS vs. Liquid-Phase — Comparison of solid-phase and liquid-phase synthesis approaches
• Manufacturing Workflow — End-to-end manufacturing process flow
• Production Scale — From research-scale to GMP production

Core Topics¶

Solid Phase Peptide Synthesis (SPPS)¶

SPPS is the dominant method for commercial peptide production. Key stages include:

1. Resin Selection — Choosing the solid support based on C-terminal amino acid
2. Coupling — Sequential addition of protected amino acids
3. Deprotection — Removal of temporary protecting groups
4. Cleavage — Release of peptide from resin
5. Purification — Preparative HPLC to achieve target purity
6. Lyophilization — Freeze-drying to stable powder form

🔗 Related: SPPS Process Detail | Peptide Synthesizer | Purification Process